Innovative Immunotherapies
Our sustainable pipeline of immunomodulatory antibodies targets multiple cell types and key immunosuppressive or inflammatory mechanisms for the treatment of cancer and immunology and inflammation diseases (I&I).
We currently have three active Phase 1 clinical programs: the first-in-class TNFR2 agonist monoclonal antibody emunkitug (HFB200301, NCT05238883), the next-generation fully human OX40 agonist monoclonal antibody nuvustotug (HFB301001, NCT05229601), and the best-in-class BTLA antagonist monoclonal antibody HFB200603 (NCT05789069). All three programs have successfully completed dose escalation.
Our preclinical pipeline includes several programs targeting key immune cell types involved in I&I. The most advanced, HFB200604, is a best-in- class BTLA agonist antibody that has cleared IND.
| Program | Discovery | Preclinical (IND) | Phase I | Phase II/III |
|---|---|---|---|---|
| Immuno-oncology | ||||
| HFB200603*BTLA Antagonist | ||||
| Emunkitug* (HFB200301) TNFR2 Agonist | ||||
| Nuvustotug (HFB301001)OX40 Agonist | ||||
| HFB200902Gal-9 Antagonist | ||||
| HFB101110CCR8 Depletor | ||||
| Immunology & Inflammation | ||||
| HFB200604BTLA Agonist | ||||
| HFB100204CXCR5 Depletor | ||||
| HFB3024KLRG1 Depletor | ||||
| HFB2025PD-1 Depletor | ||||
| HFB2027TNFR2 Agonist | ||||
| BispecificsNovel targets | ||||
| Immuno-oncology | |||
|---|---|---|---|
| Discovery | Preclinical (IND) | Phase I | Phase II/III |
| HFB200603* | BTLA Antagonist | |||
| Emunkitug* (HFB200301) | TNFR2 Agonist | |||
| Nuvustotug (HFB301001) | OX40 Agonist | |||
| HFB200902 | Gal-9 Antagonist | |||
| HFB101110 | CCR8 Depletor | |||
| Immunology & Inflammation | |||
| Discovery | Preclinical (IND) | Phase I | Phase II/III |
| HFB200604 | BTLA Agonist | |||
| HFB100204 | CXCR5 Depletor | |||
| HFB3024 | KLRG1 Depletor | |||
| HFB2025 | PD-1 Depletor | |||
| HFB2027 | TNFR2 Agonist | |||
| Bispecifics | Novel targets | |||
*As monotherapy or in combination with anti-PD-1, Tislelizumab, supply agreement with Novartis
Publications
HFB200301 HFB200603 HFB301001 Other Programs